Spaceflight Effects of Bacterial Pathogenicity and Host Response to Infection

Job Listing No: 9740000

Spaceflight Effects of Bacterial Pathogenicity and Host Response to Infection

Moffet, QC – A recent study in our lab showed that spaceflight alters Serratia marcescens bacterial pathogenicity. In a separate study, we also demonstrated that the Drosophila melanogaster immune system is compromised. Both studies analyzed changes in gene expression after exposure to microgravity. This project will employ mutagenesis and simulated microgravity techniques for S. marcescens in conjunction with available genetic tools in Drosophila to build on these two previous studies. Our aim is to uncover molecular pathways that are important for the host response to the pathogenic S. marcescens as well as any interaction between host and pathogen that renders the bacteria more pathogenic or the host more vulnerable…. – Permanent – Full-time

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